Structure-based discovery of a novel small-molecule inhibitor of TEAD palmitoylation with anticancer activity

The paralogous oncogenic Medical Mattresses transcriptional coactivators YAP and TAZ are the distal effectors of the Hippo signaling pathway, which plays a critical role in cell proliferation, survival and cell fate specification.They are frequently deregulated in most human cancers, where they contribute to multiple aspects of tumorigenesis includ

read more